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Product name |
Clobetasol propionate |
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CAS No. |
25122-46-7 |
Density |
1.2g/cm3 |
Molecular Formula |
C25H32ClFO5 |
Flash Point(C) |
297.9+/-30.1C |
Molecular Weight |
466.97 |
Refractive index |
1.582 |
Specification
Ref Standard |
USP38 |
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Items |
Requirements |
Results |
|
Assay(HPLC,basis on drying) |
97.0%102.0% |
99.8% |
|
Appearance |
White or almost white crystalline powder |
Complies |
|
Solubility |
Practically insoluble in water,slightly soluble in benzene and diethyl ether,sparingly soluble ethanol,soluble in acetone and in dimethyl sulfoxide,in chloroform,in methanol and in dioxane |
Complies |
|
Identification(IR) |
Commplies with the standard |
Complies |
|
Specific Rotation |
+98-+104 |
+101.6 |
|
Melting Point |
about 196C |
194.0C-196.0C |
|
Residue on Ignition |
0.1% |
0.05% |
|
Loss on Drying |
2.0% |
0.31% |
|
Heavy Metals |
20ppm |
Complies |
|
Related Substances(HPLC) |
single impurity |
N.m.t 1.0% |
0.18% |
sum impurity |
N.m.t 2.5% |
0.32% |
|
Organic Volatile Impurities |
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THF |
720ppm |
Complies |
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Methanol |
3000ppm |
Complies |
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DMF |
880ppm |
Complies |
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Pyridine |
200ppm |
Complies |
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Dichloromethane |
600ppm |
Complies |
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Ethanol |
5000ppm |
Complies |
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Acetone |
5000ppm |
Complies |